Aviva PremiershipVenue: Twickenham Stoop Date: Saturday, 28 October Kick-off: 15:00 BSTCoverage: Live on BBC local radio; live scores on the BBC Sport website, app and mobile
Harlequins make six changes from the side beaten by Wasps as Mark Lambert replaces banned prop Joe Marler and hooker Elia Elia makes his first start.
Prop Will Collier and flanker James Chisholm return from injury, with Alofa Alofa named at centre.
Worcester, make four changes as the bottom club seek a first league win of the season.
Skipper Donncha O’Callaghan, winger Perry Humphreys, hooker Joe Taufete’e and flanker Sam Lewis all return.
Front row Ethan Waller, Gareth Milasinovich and Taufete’e, who scored a first-half hat-trick of tries in the are all handed a first Premiership start of the season, as is Australian stand-off Jono Lance.
Lewis deputises for former Warriors captain GJ van Velze, who is missing after suffering a head injury last weekend – his first setback since missing almost the whole of last season with a concussion problem.
Harlequins: Brown; Walker, Alofa, Roberts, Visser; Smith, Care; Lambert, Elia, Collier, Glynn, Horwill (capt), Chisholm, Robshaw, Luamanu.
Replacements: Piper, Boyce, Swainston, Matthews, Lamb, Mulchrone, Swiel, Sloan.
Worcester: Pennell; Humphreys, Olivier, Willison, Adams; Lance, Arr; Waller, Taufete’e, Milasinovich, O’Callaghan (capt), Spencer, Faosiliva, Lewis, Denton.
Replacements: Singleton, Bower, Alo, Phillips, Taylor, Dowsett, Heathcote, Howe.